

The last Sforza duke, he clung to Milan's throne in an era when his city became a prize fought over by Europe's superpowers.
Born into the storied Sforza dynasty, Francesco II's life was defined by the precariousness of his inheritance. His father, Ludovico il Moro, had lost Milan to the French, and Francesco's claim was a ghost until Emperor Charles V ejected the French in 1521, installing the young man as a client ruler. His reign was a tightrope walk between the colossal powers of France and the Habsburg Empire. He switched allegiances, joining the French-led League of Cognac, only to see his city sacked by imperial troops in 1527. Surviving a poisoning attempt, he later married Christina of Denmark, a political match meant to secure his line. His rule brought a period of relative stability and rebuilding, but his death without an heir in 1535 extinguished the Sforza line, allowing Charles V to annex Milan directly, ending an independent ducal state.
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He was the last direct descendant of Francesco Sforza, the condottiero who founded the Sforza dynasty in Milan.
His wife, Christina of Denmark, was famously painted by Hans Holbein the Younger when Henry VIII of England was considering her as a potential bride.
He survived a poisoning attempt in 1529, believed to have been orchestrated by agents of the Holy Roman Empire.
“My duchy is a prize fought over by greater powers.”