

A patient, meticulous researcher whose work with sick silkworms unveiled a fundamental truth: living microbes, not bad air or miasma, could be the cause of infectious disease.
Working in near-isolation in Lodi, Agostino Bassi conducted a quiet revolution in biology. For a quarter of a century, he studied a calamity devastating Italian silk farms: the muscardine disease that turned caterpillars into hard, white mummies. Through relentless experimentation, he proved the culprit was not a vague 'insect cholera' but a specific, living fungus that could be transmitted. Published in 1835, his work was the first to demonstrate conclusively that a microorganism caused an animal disease—decades before Pasteur and Koch. Bassi didn't stop there; he boldly extrapolated his 'contagion' theory to human illnesses like plague and syphilis. Though ignored by many contemporaries, his methodical approach laid the essential groundwork for the germ theory of disease.
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He was trained as a lawyer but abandoned the profession to pursue his passion for agricultural science.
The fungus he discovered, Beauveria bassiana, is used today as a natural insecticide in organic farming.
He suffered from eye problems and later blindness, which hampered but did not stop his research.
“The silkworm disease is caused by a living, parasitic fungus.”